Full Product Name
14-3-3 beta/zeta Antibody
Product Gene Name
anti-14-3-3 beta/zeta antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P63104
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-14-3-3 beta/zeta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-14-3-3 beta/zeta antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for 14-3-3 beta/zeta. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001129171.1
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NCBI GenBank Nucleotide #
NM_001135699.1
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UniProt Primary Accession #
P63104
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UniProt Secondary Accession #
P29213; P29312; Q32P43; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; A8K1N0; B7Z465[Other Products]
UniProt Related Accession #
P63104[Other Products]
Molecular Weight
19,333 Da
NCBI Official Full Name
14-3-3 protein zeta/delta
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
NCBI Official Symbol
YWHAZ [Similar Products]
NCBI Official Synonym Symbols
HEL4; YWHAD; KCIP-1; HEL-S-3; HEL-S-93; 14-3-3-zeta
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NCBI Protein Information
14-3-3 protein zeta/delta
UniProt Protein Name
14-3-3 protein zeta/delta
UniProt Synonym Protein Names
Protein kinase C inhibitor protein 1; KCIP-1
UniProt Gene Name
YWHAZ [Similar Products]
UniProt Synonym Gene Names
KCIP-1 [Similar Products]
NCBI Summary for 14-3-3 beta/zeta
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for 14-3-3 beta/zeta
14-3-3 zeta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Phosphorylation apparently disrupts homodimerization.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q22.3
Cellular Component: cell-cell adherens junction; cytoplasm; cytoplasmic vesicle membrane; cytosol; extracellular space; focal adhesion; nucleoplasm; nucleus
Molecular Function: identical protein binding; protein binding; protein kinase binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: establishment of Golgi localization; negative regulation of apoptosis; platelet activation; regulation of mRNA stability; signal transduction
Research Articles on 14-3-3 beta/zeta
1. The 14-3-3 family is dysregulated in schizophrenia, perhaps owing to specific regulatory mechanisms; the expression of the 14-3-3 epsilon, theta and zeta isoforms could be useful indicators of disease severity.
Precautions
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Disclaimer
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