frizzled homolog 10 (Drosophila), ELISA Kit

Human Frizzled-10 (FZD10) ELISA kit; CD350; FZ-10; FzE7; hFz10; frizzled 10; frizzled homolog 10 (Drosophila)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of FZD10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9318916 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the frizzled homolog 10 (Drosophila) (FZD10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FZD10. The ELISA analytical biochemical technique of the MBS9318916 kit is based on FZD10 antibody-FZD10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FZD10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FZD10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

65,336 Da

frizzled class receptor 10

frizzled-10; frizzled homolog 10; frizzled family receptor 10; frizzled 10, seven transmembrane spanning receptor

Frizzled-10

Fz-10; hFz10  [Similar Products]

FZD10_HUMAN

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

FZD10: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: Receptor, GPCR; GPCR, Fz/Smo family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: cell surface; integral to plasma membrane; cytoplasm

Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; protein binding

Biological Process: neuron differentiation; positive regulation of JNK activity; G-protein coupled receptor protein signaling pathway; regulation of actin cytoskeleton organization and biogenesis; Wnt receptor signaling pathway through beta-catenin

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