Product Name
FAM58A, cDNA Clone
Full Product Name
FAM58A cDNA Clone
Product Gene Name
FAM58A cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggaggcag gtgtcaagct agggatgcgg tccattccca ttgccactgc ttgcaccatt taccataagt tcttttgcga gaccaacctg gacgcctatg acccttacct gattgccatg tcttcaattt acttggccgg caaagtggaa gagcagcacc tgcggactcg tgacatcatc aatgtgtcca acaggtactt taacccaagc ggtgagcccc tggaattgga ctcccgcttc tgggaactcc gggacagcat cgtgcagtgt gagcttctca tgctgagagt tctgcgcttc caggtctcct tccagcatcc acacaagtac ctgctccact acctggtttc cctccagaac tggctgaacc gccacagctg gcagcggacc cctgttgccg tcaccgcctg ggccctgctg cgggacagct accatggggc gctgtccctc cgcttccagg cccagcacat cgccgtggcg gtgctctacc tggccctgca ggtctacgga gttgaggtgc ccgccgaggt cgaggctgag aagccgtggt ggcaggtgtt taatgacgac cttaccaagc caatcattga taatattgtg tctgatctca ttcagattta taccatggac acagagatcc cctaa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FAM58A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FAM58A. It may not necessarily be applicable to this product.
NCBI Accession #
BC007232
[Other Products]
UniProt Secondary Accession #
Q2I380; Q330J9; Q96IU5; Q9BUU1[Other Products]
UniProt Related Accession #
Q8N1B3[Other Products]
Molecular Weight
26,114 Da
NCBI Official Full Name
Homo sapiens family with sequence similarity 58, member A, mRNA
NCBI Official Synonym Full Names
family with sequence similarity 58 member A
NCBI Official Symbol
FAM58A [Similar Products]
NCBI Official Synonym Symbols
STAR
[Similar Products]
NCBI Protein Information
cyclin-related protein FAM58A
UniProt Protein Name
Cyclin-related protein FAM58A
UniProt Synonym Protein Names
CDK10-activating cyclin; Cyclin-M
Protein Family
Cyclin-related protein
UniProt Gene Name
FAM58A [Similar Products]
UniProt Entry Name
FA58A_HUMAN
NCBI Summary for FAM58A
Mutations in this gene have been shown to cause an X-linked dominant STAR syndrome that typically manifests syndactyly, telecanthus and anogenital and renal malformations. The protein encoded by this gene contains a cyclin-box-fold domain which suggests it may have a role in controlling nuclear cell division cycles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
UniProt Comments for FAM58A
FAM58B: May have a role in cell proliferation. Defects in FAM58A are the cause of toe syndactyly, telecanthus, and anogenital and renal malformations (STAR); also known as STAR syndrome or syndactyly with renal and anogenital malformations. Belongs to the cyclin family. Cyclin-like FAM58 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; nucleus
Molecular Function: cyclin-dependent protein kinase regulator activity; protein binding
Biological Process: positive regulation of cyclin-dependent protein kinase activity; positive regulation of transcription from RNA polymerase II promoter
Disease: Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations
Research Articles on FAM58A
1. Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations.
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Disclaimer
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