Germ Cell Nuclear Factor (GCNF), Polyclonal Antibody

NR6A1; NR6-A1; GCNF1; NR61; RTR; Nuclear Receptor Subfamily 6, Group A, Member 1; Retinoid receptor-related testis-specific receptor

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-GCNF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

53,908 Da

nuclear receptor subfamily 6 group A member 1

nuclear receptor subfamily 6 group A member 1

Nuclear receptor subfamily 6 group A member 1

GCNF; GCNF; hGCNF; RTR; hRTR  [Similar Products]

This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

NR6A1: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis. Homodimer. Interacts with UIMC1. Shows highest expression in the germ cells of the ***** testis. Belongs to the nuclear hormone receptor family. NR6 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: nucleoplasm; nucleus; transcription factor complex

Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; sequence-specific DNA binding

Biological Process: cell proliferation; gamete generation; negative regulation of transcription from RNA polymerase II promoter; spermatogenesis; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter

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