Full Product Name
PAX3, NT (Paired Box Protein Pax-3, HUP2)
Product Synonym Names
Anti -PAX3, NT (Paired Box Protein Pax-3, HUP2)
Product Gene Name
anti-PAX3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (223064606..223163715, complement). Location: 2q35-q37; 2q35
3D Structure
ModBase 3D Structure for P23760
Specificity
Recognizes human PAX3.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the N-terminal region of human PAX3 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-PAX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PAX3 antibody
PAX3 probable is a transcription factor associated with development of alveolar rhabdomyosarcoma.
Product Categories/Family for anti-PAX3 antibody
Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-PAX3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PAX3 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
NCBI/Uniprot data below describe general gene information for PAX3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_852122.1
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NCBI GenBank Nucleotide #
NM_181457.3
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UniProt Primary Accession #
P23760
[Other Products]
UniProt Secondary Accession #
Q16448; Q53T90; Q6GSJ9[Other Products]
UniProt Related Accession #
P23760; Q12777; Q494Z3; Q494Z4; Q86UQ2; Q86UQ3[Other Products]
Molecular Weight
52,968 Da[Similar Products]
NCBI Official Full Name
paired box protein Pax-3 isoform PAX3
NCBI Official Synonym Full Names
paired box 3
NCBI Official Symbol
PAX3 [Similar Products]
NCBI Official Synonym Symbols
WS1; WS3; CDHS; HUP2; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778
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NCBI Protein Information
paired box protein Pax-3; OTTHUMP00000164207; OTTHUMP00000164208; OTTHUMP00000164209; OTTHUMP00000202744; OTTHUMP00000202745; OTTHUMP00000202746; OTTHUMP00000205137; OTTHUMP00000224703; paired domain gene 3; paired domain gene HuP2; paired box homeotic gene 3
UniProt Protein Name
Paired box protein Pax-3
UniProt Synonym Protein Names
HuP2
Protein Family
Paired box protein
UniProt Gene Name
PAX3 [Similar Products]
UniProt Synonym Gene Names
HUP2 [Similar Products]
UniProt Entry Name
PAX3_HUMAN
NCBI Summary for PAX3
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq]
UniProt Comments for PAX3
PAX3: Probable transcription factor associated with development of alveolar rhabdomyosarcoma. Can bind to DNA as a heterodimer with PAX7. Interacts with DAXX. Belongs to the paired homeobox family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; muscle development; apoptosis; positive regulation of transcription, DNA-dependent; heart development; pigmentation during development; neuron fate commitment; negative regulation of transcription from RNA polymerase II promoter; cell proliferation; organ morphogenesis; sensory perception of sound; neural tube closure; positive regulation of cell proliferation; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis; neural crest cell migration
Disease: Waardenburg Syndrome, Type 3; Rhabdomyosarcoma 2; Craniofacial-deafness-hand Syndrome; Waardenburg Syndrome, Type 1
Research Articles on PAX3
1. Data present two PPDII families with fully penetrant point mutations in ultra-conserved predicted s for transcription factors SOX9 and PAX3, two possible candidates for regulating SHH expression.
Precautions
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Disclaimer
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