Product Name
PEPCK-C, Polyclonal Antibody
Full Product Name
PEPCK-C Polyclonal Antibody
Product Gene Name
anti-PEPCK-C antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35558
Other Notes
Small volumes of anti-PEPCK-C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PEPCK-C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002582.3
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NCBI GenBank Nucleotide #
NM_002591.3
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UniProt Primary Accession #
P35558
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UniProt Secondary Accession #
Q8TCA3; Q9UJD2; A8K437; B4DT64[Other Products]
UniProt Related Accession #
P35558[Other Products]
Molecular Weight
34,156 Da
NCBI Official Full Name
phosphoenolpyruvate carboxykinase, cytosolic
NCBI Official Synonym Full Names
phosphoenolpyruvate carboxykinase 1
NCBI Official Symbol
PCK1 [Similar Products]
NCBI Official Synonym Symbols
PCKDC; PEPCK1; PEPCKC; PEPCK-C
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NCBI Protein Information
phosphoenolpyruvate carboxykinase, cytosolic [GTP]
UniProt Protein Name
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
UniProt Gene Name
PCK1 [Similar Products]
UniProt Synonym Gene Names
PEPCK-C [Similar Products]
NCBI Summary for PEPCK-C
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for PEPCK-C
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Research Articles on PEPCK-C
1. Study investigated the molecular basis of such effects focusing on a commonly studied polymorphism in pig Pgc1alpha, which changes a cysteine at position 430 (WT) of the protein to a serine (C430S); found that differential O-GlcNAcylation of Pgc1alpha regulates PCK1 activity and this molecular mechanism could explain at least in part the epistatic interaction between both genes.
Precautions
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