INSL3, Polyclonal Antibody

Rabbit Polyclonal (IgG) to Human INSL3; Human INSL3; Insulin-like 3 (Leydig cell); Insulin-like 3; Ley-I-L; Leydig insulin-like peptide; Relaxin-like factor; RLNL; Tyrosine protein kinase jak3m; Relaxin-like factor b; Leydig insulin -like hormone

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

INSL3 antibody detects endogenous levels of INSL3.

Immunoaffinity purified

PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

1 mg/ml (lot specific)

Store at -20 degree C.

Small volumes of anti-INSL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

INSL3 Antibody, Insulin-like 3 (Leydig cell) Antibody, Insulin-like 3 Antibody, Ley-I-L Antibody, Leydig insulin-like peptide Antibody, Relaxin-like factor Antibody, RLNL Antibody, Tyrosine protein kinase jak3m Antibody, Relaxin-like factor b Antibody, Leydig insulin -like hormone Antibody Description: INSL3 is a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)

ELISA (1:10000)
IHC-P (20 ug/ml)
WB (1:500 - 1:1000)

Anti-INSL3 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

Western blot of extracts from MCF7 cells, using INSL3 antibody.

16,872 Da

insulin like 3

insulin-like 3

Insulin-like 3

RLF; RLNL; Ley-I-L  [Similar Products]

INSL3_HUMAN

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

INSL3: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO); also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low. Belongs to the insulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.2-p12

Cellular Component: extracellular region; extracellular space; perinuclear region of cytoplasm

Molecular Function: G-protein-coupled receptor binding; hormone activity; insulin receptor binding; protease binding; receptor binding

Biological Process: cell-cell signaling; G-protein signaling, adenylate cyclase inhibiting pathway; in utero embryonic development; male gonad development; negative regulation of apoptosis; negative regulation of cell proliferation; oocyte maturation; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; spermatogenesis

Disease: Cryptorchidism, Unilateral Or Bilateral

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