toll-like receptor adaptor molecule 1, ELISA Kit

Mouse TIR domain-containing adapter molecule 1 (TICAM1) ELISA kit; MGC35334; PRVTIRB; TICAM-1; TRIF; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adaptor molecule 1; toll-like receptor adaptor molecule 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of TICAM1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9323601 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the toll-like receptor adaptor molecule 1 (TICAM1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TICAM1. The ELISA analytical biochemical technique of the MBS9323601 kit is based on TICAM1 antibody-TICAM1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TICAM1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TICAM1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

79,230 Da

toll-like receptor adaptor molecule 1

TIR domain-containing adapter molecule 1; TIR domain-containing adaptor inducing interferon-beta; TIR domain-containing adapter protein inducing IFN-beta; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

TIR domain-containing adapter molecule 1

Trif; TICAM-1; TIR domain-containing adapter protein inducing IFN-beta  [Similar Products]

TCAM1_MOUSE

TICAM1: an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1.

Protein type: Apoptosis; Adaptor/scaffold

Molecular Function: protein binding; signal transducer activity; protein kinase binding

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; immune system process; apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of protein homodimerization activity; positive regulation of interleukin-6 production; response to lipopolysaccharide; signal transduction; positive regulation of tumor necrosis factor production; positive regulation of natural killer cell activation; activation of NF-kappaB transcription factor; positive regulation of chemokine biosynthetic process; response to exogenous dsRNA; positive regulation of protein ubiquitination; positive regulation of B cell activation; positive regulation of interferon-beta biosynthetic process; macrophage activation during immune response; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon type I production; positive regulation of B cell proliferation; innate immune response; inflammatory response; defense response to virus

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