Product Name
Tyk 2 (TYK2), Polyclonal Antibody
Full Product Name
Tyk 2 (Phospho-Tyr292) Antibody
Product Gene Name
anti-TYK2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P29597
Specificity
Tyk 2 (Phospho-Tyr292) antibody detects endogenous levels of Tyk 2 only when phosphorylated at Tyr292.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
Form/Format
Rabbit IgG in phosphate buffered saline (Phospho-without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Phospho
Modification Sites
H:Y292
Immunogen
The antiserum was produced against synthesized phospho-peptide derived from human Tyk 2 around the phosphorylation site of Tyr292.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-TYK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TYK2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-TYK2 antibody
WB: 1:500~1:1000
ELISA: 1:10000
ELISA (EIA) of anti-TYK2 antibody
Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Tyk 2 (Phospho-Tyr292) Antibody
Western Blot (WB) of anti-TYK2 antibody
Western blot analysis of lysates from 293 cells, using phospho-Thryk 2 (Phospho-Tyr292) antibody.
NCBI/Uniprot data below describe general gene information for TYK2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003322.3
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NCBI GenBank Nucleotide #
NM_003331.4
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UniProt Primary Accession #
P29597
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UniProt Secondary Accession #
Q6QB10; Q96CH0[Other Products]
UniProt Related Accession #
P29597[Other Products]
NCBI Official Full Name
non-receptor tyrosine-protein kinase TYK2
NCBI Official Synonym Full Names
tyrosine kinase 2
NCBI Official Symbol
TYK2 [Similar Products]
NCBI Official Synonym Symbols
JTK1; IMD35
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NCBI Protein Information
non-receptor tyrosine-protein kinase TYK2
UniProt Protein Name
Non-receptor tyrosine-protein kinase TYK2
Protein Family
Non-receptor tyrosine-protein kinase
UniProt Gene Name
TYK2 [Similar Products]
NCBI Summary for TYK2
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
UniProt Comments for TYK2
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Research Articles on TYK2
1. TYK2 polymorphism is not associated with Dermatomyositis /Polymyositis in the Chinese Han population
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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