Full Product Name
IL-31 Polyclonal Antibody
Product Synonym Names
Interleukin-31; IL-31; IL31
Product Gene Name
anti-IL-31 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6EBC2
Purity/Purification
Affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Immunogen
Synthetic peptide from human protein at AA range: 21-70
Storage Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-IL-31 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IL-31 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-IL-31 antibody
WB: 1:500-2000
ELISA: 1:10000-20000
NCBI/Uniprot data below describe general gene information for IL-31. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001014358.1
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NCBI GenBank Nucleotide #
NM_001014336.1
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UniProt Primary Accession #
Q6EBC2
[Other Products]
UniProt Secondary Accession #
A2RUQ1[Other Products]
UniProt Related Accession #
Q6EBC2[Other Products]
NCBI Official Full Name
interleukin-31
NCBI Official Synonym Full Names
interleukin 31
NCBI Official Symbol
IL31 [Similar Products]
NCBI Official Synonym Symbols
IL-31
[Similar Products]
NCBI Protein Information
interleukin-31
UniProt Protein Name
Interleukin-31
UniProt Gene Name
IL31 [Similar Products]
UniProt Synonym Gene Names
IL-31 [Similar Products]
NCBI Summary for IL-31
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
UniProt Comments for IL-31
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (). Induces RETNLA and serum amyloid A protein expression in macrophages ().
Research Articles on IL-31
1. Obtained results, as well as literature data, show that lower concentration of IL-31 in patients' serum may be correlated with its role in JAK/STAT signaling pathway which is involved in development of autoimmune blistering disease
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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