transforming growth factor, beta receptor 1, ELISA Kit

Human TGF-beta receptor type-1 (TGFBR1) ELISA kit; AAT5; ACVRLK4; ALK-5; ALK5; LDS1A; LDS2A; SKR4; TGFR-1; activin A receptor type II-like kinase; 53kD; activin A receptor type II-like kinase; 53kDa; activin receptor-like kinase 5; serine/threonine-pro; transforming growth factor; beta receptor 1

For Research Use Only. Not for use in diagnostic procedures.

This assay has high sensitivity and excellent specificity for detection of human TGFBR1. No significant cross-reactivity or interference between human TGFBR1 and analogues was observed.

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of TGFBR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS919082 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the transforming growth factor, beta receptor 1 (TGFBR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TGFBR1. The ELISA analytical biochemical technique of the MBS919082 kit is based on TGFBR1 antibody-TGFBR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TGFBR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TGFBR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for TGFBR1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any TGFBR1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TGFBR1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TGFBR1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

47,690 Da

transforming growth factor, beta receptor 1

TGF-beta receptor type-1; tbetaR-I; TGF-beta receptor type I; TGF-beta type I receptor; activin receptor-like kinase 5; multiple self-healing squamous epithelioma; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; transforming growth factor-beta receptor type I; activin A receptor type II-like protein kinase of 53kD; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)

TGF-beta receptor type-1

ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I  [Similar Products]

TGFR1_HUMAN

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.

Protein type: Protein kinase, TKL; Kinase, protein; Receptor, misc.; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; EC 2.7.11.30; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: tight junction; membrane; cell; plasma membrane; receptor complex; endosome

Molecular Function: metal ion binding; punt binding; protein kinase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; growth factor binding; receptor signaling protein activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: lens development in camera-type eye; blastocyst development; collagen fibril organization; wound healing; activation of MAPKK activity; apoptosis; regulation of protein ubiquitination; heart development; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; cell motility involved in cell locomotion; activin receptor signaling pathway; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; regulation of transcription, DNA-dependent; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; germ cell migration; angiogenesis; kidney development; cell cycle arrest; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; neuron fate commitment; positive regulation of cell motility; embryonic cranial skeleton morphogenesis; positive regulation of cell growth; parathyroid gland development; endothelial cell activation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; mesenchymal cell differentiation; regulation of gene expression; skeletal morphogenesis; regulation of protein binding; negative regulation of endothelial cell proliferation; epithelial to mesenchymal transition; endothelial cell migration; artery morphogenesis; positive regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To

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