Neuropathy target esterase, ELISA Kit

Neuropathy target esterase; Patatin-like phospholipase domain-containing protein 6; Pnpla6; Nte; 3.1.1.5

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of Pnpla6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2882759 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neuropathy target esterase (Pnpla6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Pnpla6. The ELISA analytical biochemical technique of the MBS2882759 kit is based on Pnpla6 antibody-Pnpla6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Pnpla6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Pnpla6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

129,347 Da

patatin-like phospholipase domain containing 6

neuropathy target esterase

Neuropathy target esterase

Nte  [Similar Products]

PLPL6_MOUSE

NTE: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Defects in PNPLA6 are the cause of spastic paraplegia autosomal recessive type 39 (SPG39); also known as NTE-related motor neuron disorder (NTEMND). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG39 is associated with a motor axonopathy affecting upper and lower limbs and resulting in progressive wasting of distal upper and lower extremity muscles. Belongs to the NTE family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.5; Membrane protein, integral; Hydrolase

Cellular Component: endoplasmic reticulum; integral to membrane; membrane

Molecular Function: hydrolase activity; lysophospholipase activity

Biological Process: angiogenesis; lipid catabolic process; lipid metabolic process; metabolic process; organ morphogenesis; phosphatidylcholine metabolic process

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