Product Name
Myelin protein P0 (Mpz), Recombinant Protein
Full Product Name
Recombinant Mouse Myelin protein P0 (Mpz), partial
Product Gene Name
Mpz recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
30-153. Partial, provide the complete extracellular domain.
Sequence
IVVYTDREIY GAVGSQVTLH CSFWSSEWVS DDISFTWRYQ PEGGRDAISI FHYAKGQPYI DEVGAFKERI QWVGDPRWKD GSIVIHNLDY SDNGTFTCDV KNPPDIVGKT SQVTLYVFEK VPTR
3D Structure
ModBase 3D Structure for P27573
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Mpz recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Mpz. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001302428.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001315499.1
[Other Products]
UniProt Primary Accession #
P27573
[Other Products]
UniProt Secondary Accession #
Q542C9[Other Products]
UniProt Related Accession #
P27573[Other Products]
Molecular Weight
27,622 Da
NCBI Official Full Name
myelin protein P0 isoform MPZ
NCBI Official Synonym Full Names
myelin protein zero
NCBI Official Symbol
Mpz [Similar Products]
NCBI Official Synonym Symbols
P0; Mpp; P-zero
[Similar Products]
NCBI Protein Information
myelin protein P0
UniProt Protein Name
Myelin protein P0
UniProt Synonym Protein Names
Myelin peripheral protein; MPP; Myelin protein zero
Protein Family
Myelin protein
UniProt Gene Name
Mpz [Similar Products]
UniProt Synonym Gene Names
P0; MPP [Similar Products]
NCBI Summary for Mpz
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2015]
UniProt Comments for Mpz
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
Research Articles on Mpz
1. Data show that both transgenic Wnt1-cre and P0-cre are similarly effective in deleting beta-catenin in the neural crest.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
