Full Product Name
TYK2 (Phospho-Tyr1054) Antibody
Product Gene Name
anti-TYK2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P29597
Species Reactivity
Human, Mouse
Specificity
TYK2 (phospho-Tyr1054) antibody detects endogenous levels of TYK2 only when phosphorylated at tyrosine 1054.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human TYK2 around the phosphorylation site of tyrosine 1054 (H-E-YP-Y-R).
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-TYK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-TYK2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-TYK2 antibody
Western Blot (WB)
Application Notes for anti-TYK2 antibody
WB: 1:500-1:1000
Western Blot (WB) of anti-TYK2 antibody
Western blot analysis of extracts from HT-29 cells untreated or treated with Anisomycin (20min), using TYK2 (phospho-Tyr1054) antibody.
NCBI/Uniprot data below describe general gene information for TYK2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003322.3
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NCBI GenBank Nucleotide #
NM_003331.4
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UniProt Primary Accession #
P29597
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UniProt Secondary Accession #
Q6QB10; Q96CH0[Other Products]
UniProt Related Accession #
P29597[Other Products]
Molecular Weight
133,650 Da
NCBI Official Full Name
non-receptor tyrosine-protein kinase TYK2
NCBI Official Synonym Full Names
tyrosine kinase 2
NCBI Official Symbol
TYK2 [Similar Products]
NCBI Official Synonym Symbols
JTK1; IMD35
[Similar Products]
NCBI Protein Information
non-receptor tyrosine-protein kinase TYK2
UniProt Protein Name
Non-receptor tyrosine-protein kinase TYK2
Protein Family
Non-receptor tyrosine-protein kinase
UniProt Gene Name
TYK2 [Similar Products]
NCBI Summary for TYK2
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
UniProt Comments for TYK2
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Product References and Citations for anti-TYK2 antibody
Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730. Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.
Research Articles on TYK2
1. New ELAVL1-TYK2 fusion gene is oncogenic in acute myeloid leukemia.
Precautions
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Disclaimer
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