Product Name
Antithrombin (AT), Polyclonal Antibody
Full Product Name
Cy3-Linked Polyclonal Antibody to Antithrombin (AT)
Product Synonym Names
AT3; ATIII; SERPINC1; Anti-Thrombin Antibodies; Serpin Peptidase Inhibitor Clade C Member 1; Coding Sequence Signal Peptide Antithrombin Part 1
Product Gene Name
anti-AT antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Antithrombin (MBS2032879)
Cy3 Conjugated Antibody: Antithrombin (AT) (MBS2064831)
Matching Pairs
Cy3 Conjugated Antibody: Antithrombin (AT) (MBS2064831)
Immunogen: Antithrombin (MBS2033262)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Concentration
200ug/ml (lot specific)
Immunogen
AT (Met1~Ser259)
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2032879
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-AT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AT antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for AT. It may not necessarily be applicable to this product.
NCBI Accession #
CAA48690.1
[Other Products]
UniProt Secondary Accession #
P78439; P78447; Q13815; Q5TC78; Q7KZ43; Q7KZ97; Q9UC78; B2R6P0[Other Products]
UniProt Related Accession #
P01008[Other Products]
Molecular Weight
52,602 Da
NCBI Official Full Name
antithrombin
NCBI Official Synonym Full Names
serpin family C member 1
NCBI Official Symbol
SERPINC1 [Similar Products]
NCBI Official Synonym Symbols
AT3; AT3D; ATIII; THPH7
[Similar Products]
NCBI Protein Information
antithrombin-III
UniProt Protein Name
Antithrombin-III
UniProt Synonym Protein Names
Serpin C1
UniProt Gene Name
SERPINC1 [Similar Products]
UniProt Synonym Gene Names
AT3; ATIII [Similar Products]
NCBI Summary for AT
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
UniProt Comments for AT
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Research Articles on AT
1. Our studies of ATIII in-cell folding reveal a surprising, biased order of disulfide bond formation, with early formation of the C-terminal disulfide, before formation of the N-terminal disulfides, critical for folding to the active, metastable state
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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