POU domain, class 3, transcription factor 4, ELISA Kit

POU domain, class 3, transcription factor 4; Brain-specific homeobox/POU domain protein 4; Brain-4; Brn-4; Octamer-binding protein 9; Oct-9; Octamer-binding transcription factor 9; OTF-9

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of POU3F4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2882903 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the POU domain, class 3, transcription factor 4 (POU3F4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing POU3F4. The ELISA analytical biochemical technique of the MBS2882903 kit is based on POU3F4 antibody-POU3F4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect POU3F4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, POU3F4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

39,427 Da

POU class 3 homeobox 4

POU domain, class 3, transcription factor 4

POU domain, class 3, transcription factor 4

BRN4; OTF9; Brain-4; Brn-4; Oct-9; OTF-9  [Similar Products]

PO3F4_HUMAN

This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]

Oct9: Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. Defects in POU3F4 are a cause of deafness X-linked type 2 (DFNX2). A mixed type of deafness characterized by both conductive hearing loss resulting from stapes (perilymphatic gusher) fixation and progressive sensorineural deafness. Belongs to the POU transcription factor family. Class- 3 subfamily.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: Xq21.1

Cellular Component: nucleus

Molecular Function: AT DNA binding; transcription factor activity

Biological Process: forebrain neuron differentiation; regulation of transcription from RNA polymerase II promoter; sensory perception of sound; transcription from RNA polymerase II promoter

Disease: Deafness, X-linked 2

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