Full Product Name
BCHE Antibody
Product Gene Name
anti-BCHE antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P06276
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-BCHE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BCHE antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for BCHE. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000046.1
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NCBI GenBank Nucleotide #
NP_000046.1
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UniProt Primary Accession #
P06276
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UniProt Secondary Accession #
A8K7P8[Other Products]
UniProt Related Accession #
P06276[Other Products]
Molecular Weight
68,418 Da
NCBI Official Full Name
cholinesterase
NCBI Official Synonym Full Names
butyrylcholinesterase
NCBI Official Symbol
BCHE [Similar Products]
NCBI Official Synonym Symbols
E1; CHE1; CHE2
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NCBI Protein Information
cholinesterase
UniProt Protein Name
Cholinesterase
UniProt Synonym Protein Names
Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase
Protein Family
Cholinesterase
UniProt Gene Name
BCHE [Similar Products]
UniProt Synonym Gene Names
CHE1 [Similar Products]
NCBI Summary for BCHE
This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]
UniProt Comments for BCHE
BCHE: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family.
Protein type: EC 3.1.1.8; Hydrolase; Nuclear envelope; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q26.1
Cellular Component: extracellular region
Molecular Function: acetylcholinesterase activity; cholinesterase activity; hydrolase activity, acting on ester bonds; identical protein binding
Biological Process: cocaine metabolic process
Research Articles on BCHE
1. the molecular mechanisms by which point mutations may lead to silent BChE variant or alter catalytic activity, is reported.
Precautions
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Disclaimer
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