Full Product Name
BCHE Antibody
Product Synonym Names
Cholinesterase; Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase; BCHE; CHE1
Product Gene Name
anti-BCHE antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P06276
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Cholinesterase protein (311-524AA)
Conjugation
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-BCHE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BCHE antibody
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Product Categories/Family for anti-BCHE antibody
Neuroscience; Metabolism; Signal transduction
Applications Tested/Suitable for anti-BCHE antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-BCHE antibody
WB: 1:500-1:5000
IF: 1:50-1:200
Western Blot (WB) of anti-BCHE antibody
Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: BCHE antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69 KDa
Observed band size: 69 KDa
Immunofluorescence (IF) of anti-BCHE antibody
Immunofluorescent analysis of Hela cells using MBS7103335 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
NCBI/Uniprot data below describe general gene information for BCHE. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000046.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000055.3
[Other Products]
UniProt Primary Accession #
P06276
[Other Products]
UniProt Secondary Accession #
A8K7P8[Other Products]
UniProt Related Accession #
P06276[Other Products]
Molecular Weight
68,418 Da
NCBI Official Full Name
cholinesterase
NCBI Official Synonym Full Names
butyrylcholinesterase
NCBI Official Symbol
BCHE [Similar Products]
NCBI Official Synonym Symbols
E1; CHE1; CHE2
[Similar Products]
NCBI Protein Information
cholinesterase
UniProt Protein Name
Cholinesterase
UniProt Synonym Protein Names
Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase
Protein Family
Cholinesterase
UniProt Gene Name
BCHE [Similar Products]
UniProt Synonym Gene Names
CHE1 [Similar Products]
NCBI Summary for BCHE
This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]
UniProt Comments for BCHE
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Research Articles on BCHE
1. BCHE-K* positive subjects (and APOE-epsilon4) display an earlier age of onset of Alzheimer's Disease and an accelerated cognitive decline.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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