CDC6, Monoclonal Antibody

Cell division control protein 6 homolog; cell division cycle 6 homolog(S. cerevisiae); CDC18L; HsCdc18; p62(cdc6); CELL DIVISION CYCLE 18, S. POMBE, HOMOLOG-LIKE; CDC6(cell division cycle 6, S. cerevisiae) homolog; CELL CYCLE CONTROLLER CDC6; CDC6-related protein; Cdc18-related protein

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

IMD-6

Mouse

Ascites

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-CDC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: Mouse IgG monoclonal antibody for CDC6, cell division cycle 6 homolog (S. cerevisiae) (CDC6) detection. Tested with WB in Human. No cross reactivity with other proteins. Uniprot ID: Q99741
Background: In yeasts, Cdc6(Saccharomyces cerevisiae) and Cdc18(Schizosaccharomyces pombe) associate with the origin recognition complex(ORC) proteins to render cells competent for DNA replication. Cdc6 is overexpressed in human cancers, where it has a critical regulatory role in addition to DNA replication. Yan et al.(1998) showed that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues in intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. They conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.

Western Blot (WB)

62,720 Da

cell division cycle 6

cell division control protein 6 homolog; p62(cdc6); CDC6-related protein; cdc18-related protein; cell division cycle 6 homolog; CDC6 cell division cycle 6 homolog

Cell division control protein 6 homolog

CDC18L; HsCdc18; HsCDC6  [Similar Products]

CDC6_HUMAN

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

CDC6: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: nucleoplasm; Golgi apparatus; spindle pole; cytoplasm; spindle midzone; nucleus; cytosol

Molecular Function: protein binding; nucleotide binding; chromatin binding; kinase binding; ATP binding

Biological Process: positive regulation of cytokinesis; mitosis; traversing start control point of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; positive regulation of chromosome segregation; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; cell division; negative regulation of DNA replication; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; DNA replication checkpoint; DNA replication; G1/S transition of mitotic cell cycle

Disease: Meier-gorlin Syndrome 5

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