TSPYL1, Polyclonal Antibody

TSPYL

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purification

2mg/ml (lot specific)

Store at -20 degree C. Avoid freeze/thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-TSPYL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). 

ELISA (EIA), Western Blot (WB)

ELISA: 1:2000-5000
WB: 1:500-2000

Western Blot analysis of Mouse brain and heart tissue using TSPYL1 Polyclonal Antibody at dilution of 1/200

49 kDa

TSPY like 1

testis-specific Y-encoded-like protein 1

Testis-specific Y-encoded-like protein 1

TSPYL; TSPY-like protein 1  [Similar Products]

TSYL1_HUMAN

The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009]

TSPYL1: Defects in TSPYL1 are the cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). SIDDT is an autosomal recessive disorder. Affected infants appear normal at birth, develop signs of visceroautonomic dysfunction early in life, and die before 12 months of age of abrupt cardiorespiratory arrest. Features included bradycardia, hypothermia, severe gastroesophageal reflux, laryngospasm, bronchospasm, and abnormal cardiorespiratory patterns during sleep. Genotypic males with SIDDT had fetal testicular dysgenesis and ambiguous genitalia, with findings such as intraabdominal testes, dysplastic testes, deficient fetal testosterone production, fusion and rugation of the gonadal sac, and partial development of the penile shaft. Female sexual development was normal. Affected infants had an unusual staccato cry, similar to the cry of a goat. Belongs to the nucleosome assembly protein (NAP) family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 6q22.1

Cellular Component: nucleolus; nucleus

Molecular Function: enzyme binding

Disease: Sudden Infant Death With Dysgenesis Of The Testes Syndrome

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