Product Name
ADH7, cDNA Clone
Full Product Name
ADH7 cDNA Clone
Product Gene Name
ADH7 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGTTTGCAG AAATACAGAT CCAAGACAAA GACAGGATGG GCACTGCTGG AAAAGTTATT AAATGCAAAG CAGCTGTGCT TTGGGAGCAG AAGCAACCCT TCTCCATTGA GGAAATAGAA GTTGCCCCAC CAAAGACTAA AGAAGTTCGC ATTAAGATTT TGGCCACAGG AATCTGTCGC ACAGATGACC ATGTGATAAA AGGAACAATG GTGTCCAAGT TTCCAGTGAT TGTGGGACAT GAGGCAACTG GGATTGTAGA GAGCATTGGA GAAGGAGTGA CTACAGTGAA ACCAGGTGAC AAAGTCATCC CTCTCTTTCT GCCACAATGT AGAGAATGCA ATGCTTGTCG CAACCCAGAT GGCAACCTTT GCATTAGGAG CGATATTACT GGTCGTGGAG TACTGGCTGA TGGCACCACC AGATTTACAT GCAAGGGCAA ACCAGTCCAC CACTTCATGA ACACCAGTAC ATTTACCGAG TACACAGTGG TGGATGAATC TTCTGTTGCT AAGATTGATG ATGCAGCTCC TCCTGAGAAA GTCTGTTTAA TTGGCTGTGG GTTTTCCACT GGATATGGCG CTGCTGTTAA AACTGGCAAG GTCAAACCTG GTTCCACTTG CGTCGTCTTT GGCCTGGGAG GAGTTGGCCT GTCAGTCATC ATGGGCTGTA AGTCAGCTGG TGCATCTAGG ATCATTGGGA TTGACCTCAA CAAAGACAAA TTTGAGAAGG CCATGGCTGT AGGTGCCACT GAGTGTATCA GTCCCAAGGA CTCTACCAAA CCCATCAGTG AGGTGCTGTC AGAAATGACA GGCAACAACG TGGGATACAC CTTTGAAGTT ATTGGGCATC TTGAAACCAT GATTGATGCC CTGGCATCCT GCCACATGAA CTATGGGACC AGCGTGGTTG TAGGAGTTCC TCCATCAGCC AAGATGCTCA CCTATGACCC GATGTTGCTC TTCACTGGAC GCACATGGAA GGGATGTGTC TTTGGAGGTT TGAAAAGCAG AGATGATGTC CCAAAACTAG TGACTGAGTT CCTGGCAAAG AAATTTGACC TGGACCAGTT GATAACTCAT GTTTTACCAT TTAAAAAAAT CAGTGAAGGA TTTGAGCTGC TCAATTCAGG ACAAAGCATT CGAACGGTCC TGACGTTTTG A
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ADH7 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ADH7. It may not necessarily be applicable to this product.
NCBI Accession #
BC131512
[Other Products]
UniProt Secondary Accession #
Q13713; A2RRB6; A8MVN9; B2R760; B4DWV6[Other Products]
UniProt Related Accession #
P40394[Other Products]
Molecular Weight
42,467 Da
NCBI Official Full Name
Homo sapiens alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide, mRNA
NCBI Official Synonym Full Names
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
NCBI Official Symbol
ADH7 [Similar Products]
NCBI Official Synonym Symbols
ADH4
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NCBI Protein Information
alcohol dehydrogenase class 4 mu/sigma chain
UniProt Protein Name
Alcohol dehydrogenase class 4 mu/sigma chain
UniProt Synonym Protein Names
Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase
Protein Family
Alcohol dehydrogenase
UniProt Gene Name
ADH7 [Similar Products]
UniProt Entry Name
ADH7_HUMAN
NCBI Summary for ADH7
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
UniProt Comments for ADH7
ADH7: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - fatty acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Amino Acid Metabolism - tyrosine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.1.1.1
Chromosomal Location of Human Ortholog: 4q23-q24
Cellular Component: cytosol
Molecular Function: alcohol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; aldehyde oxidase activity; ethanol binding; receptor antagonist activity; retinol binding; retinol dehydrogenase activity
Biological Process: ethanol oxidation; fatty acid omega-oxidation; response to bacterium; response to ethanol; retinoid metabolic process
Research Articles on ADH7
1. These results suggest that variants near ADH7 may play a role in protection from alcohol dependence in this Mexican American cohort.
Precautions
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Disclaimer
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