Tyrosine Kinase 2 (Tyk2), Polyclonal Antibody

JTK1; Non-Receptor Tyrosine-Protein Kinase TYK2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-Tyk2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

133,650 Da

tyrosine kinase 2

non-receptor tyrosine-protein kinase TYK2

Non-receptor tyrosine-protein kinase TYK2

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Protein type: EC 2.7.10.2; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nucleus

Molecular Function: growth hormone receptor binding; protein binding; protein-tyrosine kinase activity

Biological Process: cell differentiation; cell migration; innate immune response; protein amino acid phosphorylation; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Immunodeficiency 35

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