Product Name
COX6B1, cDNA Clone
Product Synonym Names
COX6B; COXG; COXVIb1
Product Gene Name
COX6B1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Nucleotide Sequence: ATGGCGGAAG ACATGGAGAC CAAAATCAAG AACTACAAGA CCGCCCCTTT TGACAGCCGC TTCCCCAACC AGAACCAGAC TAGAAACTGC TGGCAGAACT ACCTGGACTT CCACCGCTGT CAGAAGGCAA TGACCGCTAA AGGAGGCGAT ATCTCTGTGT GCGAATGGTA CCAGCGTGTG TACCAGTCCC TCTGCCCCAC ATCCTGGGTC ACAGACTGGG ATGAGCAACG GGCTGAAGGC ACGTTTCCCG GGAAGATCTG A
T ranslation Sequence: MAEDMETKIK NYKTAPFDSR FPNQNQTRNC WQNYLDFHRC QKAMTAKGGD ISVCEWYQRV YQSLCPTSWV TDWDEQRAEG TFPGKI
3D Structure
ModBase 3D Structure for P14854
Chromosome Location
19q13.1
OMIM Reference Number
124089
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
Preparation and Storage
Store the plasmid at -20 degree C.
Other Notes
Small volumes of COX6B1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
COX6B1 cdna clone
COX6B1 belongs to the cytochrome c oxidase subunit 6B family and connects the two COX monomers into the physiological dimeric form. Defects in COX6B1 are a cause of mitochondrial complex IV deficiency (MT-C4D), also known as cytochrome c oxidase deficiency.
Product Categories/Family for COX6B1 cdna clone
Cancer
NCBI/Uniprot data below describe general gene information for COX6B1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001854.1
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NCBI GenBank Nucleotide #
NM_001863.4
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UniProt Primary Accession #
P14854
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UniProt Related Accession #
P14854[Other Products]
NCBI Official Full Name
cytochrome c oxidase subunit 6B1
NCBI Official Synonym Full Names
cytochrome c oxidase subunit 6B1
NCBI Official Symbol
COX6B1 [Similar Products]
NCBI Official Synonym Symbols
COXG; COX6B; COXVIb1
[Similar Products]
NCBI Protein Information
cytochrome c oxidase subunit 6B1
UniProt Protein Name
Cytochrome c oxidase subunit 6B1
UniProt Synonym Protein Names
Cytochrome c oxidase subunit VIb isoform 1; COX VIb-1
Protein Family
Cytochrome c oxidase
UniProt Gene Name
COX6B1 [Similar Products]
UniProt Synonym Gene Names
COX6B; COX VIb-1 [Similar Products]
UniProt Entry Name
CX6B1_HUMAN
NCBI Summary for COX6B1
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. [provided by RefSeq, Jan 2010]
UniProt Comments for COX6B1
COX6B1: Connects the two COX monomers into the physiological dimeric form. Defects in COX6B1 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Belongs to the cytochrome c oxidase subunit 6B family.
Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylation
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space
Molecular Function: cytochrome-c oxidase activity
Biological Process: cellular metabolic process; substantia nigra development; transmembrane transport
Disease: Mitochondrial Complex Iv Deficiency
Research Articles on COX6B1
1. p2 peptide from HIV-1 enhances HIV-1 acute infection by increasing intracellular ATP production via the activation of mitochondrial cytochrome c oxidase (MT-CO) involved in the respiratory chain
Precautions
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Disclaimer
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