Product Name
T1R3 / TAS1R3, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human T1R3 / TAS1R3
Product Synonym Names
Anti-T1R3 / TAS1R3 Antibody (N-Terminus) IHC-plus; TAS1R3; Taste receptor type 1 member 3; TR3; Sweet taste receptor T1R3; T1R3; Human T1R3; TAS1R3
Product Gene Name
anti-T1R3 antibody
[Similar Products]
Product Synonym Gene Name
TAS1R3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q7RTX0
Species Reactivity
Chimpanzee, Gorilla, Human
Predicted Reactivity: Orangutan (at least 90% immunogen sequence identity)
Specificity
Human TAS1R3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human TAS1R3. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan (90%); Marmoset (85%); Baboon, Monkey, Panda (80%).
Immunogen Type
Synthetic peptide
Immunogen
T1R3 / TAS1R3 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human TAS1R3. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan (90%); Marmoset (85%); Baboon, Monkey, Panda (80%).
Antigen Modification
N-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-T1R3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-T1R3 antibody
TAS1R3 is a Taste Receptor. TAS1R3 combines with TAS1R1 to function as an L-amino-acid receptor, and is only activated by these sweet amino acids.
Product Categories/Family for anti-T1R3 antibody
Subfamily:-Taste">Family: GPCR
Subfamily: Taste
Applications Tested/Suitable for anti-T1R3 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-T1R3 antibody
IHC-P (19 ug/ml)
Immunohistochemistry (IHC) of anti-T1R3 antibody
Anti-T1R3 / TAS1R3 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry (IHC) of anti-T1R3 antibody
Anti-T1R3 / TAS1R3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry (IHC) of anti-T1R3 antibody
Anti-T1R3 / TAS1R3 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry (IHC) of anti-T1R3 antibody
Anti-TAS1R3 antibody IHC of human tongue, taste receptor cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry (IHC) of anti-T1R3 antibody
Anti-T1R3 / TAS1R3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NCBI/Uniprot data below describe general gene information for T1R3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689414.1
[Other Products]
NCBI GenBank Nucleotide #
NM_152228.1
[Other Products]
UniProt Primary Accession #
Q7RTX0
[Other Products]
UniProt Secondary Accession #
Q5TA49; Q8NGW9[Other Products]
UniProt Related Accession #
Q7RTX0[Other Products]
Molecular Weight
93,386 Da
NCBI Official Full Name
taste receptor type 1 member 3
NCBI Official Synonym Full Names
taste receptor, type 1, member 3
NCBI Official Symbol
TAS1R3 [Similar Products]
NCBI Official Synonym Symbols
T1R3
[Similar Products]
NCBI Protein Information
taste receptor type 1 member 3; sweet taste receptor T1R3
UniProt Protein Name
Taste receptor type 1 member 3
UniProt Synonym Protein Names
Sweet taste receptor T1R3
UniProt Gene Name
TAS1R3 [Similar Products]
UniProt Synonym Gene Names
T1R3; TR3 [Similar Products]
UniProt Entry Name
TS1R3_HUMAN
NCBI Summary for T1R3
The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001 [PubMed 11326277]).[supplied by OMIM, Jan 2010]
UniProt Comments for T1R3
TAS1R3: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 3
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: plasma membrane; integral to membrane
Molecular Function: protein heterodimerization activity; sweet taste receptor activity; taste receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; sensory perception of umami taste; sensory perception of sweet taste; detection of chemical stimulus involved in sensory perception of sweet taste
Research Articles on T1R3
1. A complex molecular mechanism involving changes in the properties of both the orthosteric and non-orthosteric sites of T1R1 underlies the determination of ligand specificity in mammalian T1R1/T1R3.
Precautions
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Disclaimer
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