Full Product Name
Anti-GNL3 Mouse mAb
Product Synonym Names
CHET9; JJAZ1; KIAA0160; SUZ12
Product Gene Name
anti-GNL3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of human SUZ12 expressed in E Coli.
Other Notes
Small volumes of anti-GNL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GNL3 antibody
Entrez Summary: The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.
Applications Tested/Suitable for anti-GNL3 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for GNL3. It may not necessarily be applicable to this product.
NCBI Accession #
JAO76302.1
[Other Products]
UniProt Secondary Accession #
Q96BD9[Other Products]
UniProt Related Accession #
Q15022[Other Products]
NCBI Official Full Name
GNL3
NCBI Official Synonym Full Names
SUZ12 polycomb repressive complex 2 subunit
NCBI Official Symbol
SUZ12 [Similar Products]
NCBI Official Synonym Symbols
CHET9; JJAZ1
[Similar Products]
NCBI Protein Information
polycomb protein SUZ12
UniProt Protein Name
Polycomb protein SUZ12
UniProt Synonym Protein Names
Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog
Protein Family
Guanine nucleotide-binding protein
UniProt Gene Name
SUZ12 [Similar Products]
UniProt Synonym Gene Names
CHET9; JJAZ1; KIAA0160; ChET 9 protein [Similar Products]
NCBI Summary for GNL3
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
UniProt Comments for GNL3
SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.
Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: ESC/E(Z) complex; nucleolus; nucleoplasm; nucleus
Molecular Function: chromatin DNA binding; histone methyltransferase activity; methylated histone residue binding; protein binding
Biological Process: negative regulation of cell differentiation; negative regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent
Research Articles on GNL3
1. Mutations of SUZ12 and EED are reported to have tumor suppressive functions. (Review)
Precautions
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Disclaimer
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