Crk Like Protein (CRKL), Polyclonal Antibody

V-Crk Sarcoma Virus CT10 Oncogene Homolog(avian)-Like

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-CRKL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC)

33,777 Da

CRK like proto-oncogene, adaptor protein

crk-like protein

Crk-like protein

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytosol; endosome; extracellular exosome

Molecular Function: cadherin binding; identical protein binding; phosphotyrosine binding; protein binding; RNA binding; SH3/SH2 adaptor activity; signal transducer activity

Biological Process: activation of MAPKK activity; anterior/posterior pattern specification; blood vessel development; heart development; JNK cascade; organ morphogenesis; parathyroid gland development; positive regulation of cell proliferation; positive regulation of substrate adhesion-dependent cell spreading; Ras protein signal transduction; thymus development

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