Product Name
Glutaryl Coenzyme A Dehydrogenase (GCDH), Antibody Pair Kit
Full Product Name
Glutaryl Coenzyme A Dehydrogenase (GCDH) Antibody Pair Kit (with Standard)
Product Synonym Names
GCD; ACAD5; Glutaryl-CoA dehydrogenase, mitochondrial
Product Gene Name
GCDH antibody pair kit
[Similar Products]
Matching Pairs
Antibody: Glutaryl Coenzyme A Dehydrogenase (GCDH) (MBS2102680)
Pairing: Glutaryl Coenzyme A Dehydrogenase (GCDH) (MBS2102680)
Comments: Matched antibody pair kit containing antibody/standard combination
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Request Current Manual
3D Structure
ModBase 3D Structure for Q92947
Samples
Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates and Other Biological Fluids
Detection Range
31.2-2000ng/mL
Standard
Recombinant GCDH (Lyophilized, 1 vial-10ug)
Capture Antibody
Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL)
Detection Antibody
Biotinylated Rabbit polyclonal antibody (Liquid, 1 vial-100mug/500muL)
Producte Usage
Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits.
Antibody Support Pack
Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of GCDH antibody pair kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for GCDH antibody pair kit
Enzyme & Kinase
Applications Tested/Suitable for GCDH antibody pair kit
ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
NCBI/Uniprot data below describe general gene information for GCDH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_039663.1
[Other Products]
NCBI GenBank Nucleotide #
NM_013976.3
[Other Products]
UniProt Primary Accession #
Q92947
[Other Products]
UniProt Secondary Accession #
O14719; A8K2Z2[Other Products]
UniProt Related Accession #
Q92947[Other Products]
Molecular Weight
47,355 Da
NCBI Official Full Name
glutaryl-CoA dehydrogenase, mitochondrial isoform b
NCBI Official Synonym Full Names
glutaryl-CoA dehydrogenase
NCBI Official Symbol
GCDH [Similar Products]
NCBI Official Synonym Symbols
GCD; ACAD5
[Similar Products]
NCBI Protein Information
glutaryl-CoA dehydrogenase, mitochondrial
UniProt Protein Name
Glutaryl-CoA dehydrogenase, mitochondrial
UniProt Gene Name
GCDH [Similar Products]
UniProt Synonym Gene Names
GCD [Similar Products]
NCBI Summary for GCDH
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]
UniProt Comments for GCDH
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.
Research Articles on GCDH
1. We report the allele frequencies for three known Glutaric aciduria type I low excretors GCDH variants (M405V, V400M and R227P) and note that both the M405V and V400M variants are significantly more common in the population of African ancestry compared to the general population
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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