Full Product Name
TBX1 Antibody
Product Synonym Names
CAFS; CTHM; DGCR; DGS; DORV; T-box 1; T-box 1 transcription factor C
Product Gene Name
anti-TBX1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43435
Specificity
TBX1 Antibody detects endogenous levels of total TBX1 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human TBX1.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-TBX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TBX1 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-TBX1 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:20000
Immunofluorescence (IF) of anti-TBX1 antibody
Immunofluorescence analysis of A549 cells, using TBX1 Antibody. The picture on the right is blocked with the synthesized peptide.
Western Blot (WB) of anti-TBX1 antibody
Western blot analysis of lysates from COLO205 cells, using TBX1 Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for TBX1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005983.1
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NCBI GenBank Nucleotide #
NM_005992.1
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UniProt Primary Accession #
O43435
[Other Products]
UniProt Secondary Accession #
O43436; Q96RJ2; C6G493; C6G494[Other Products]
UniProt Related Accession #
O43435[Other Products]
NCBI Official Full Name
T-box transcription factor TBX1 isoform B
NCBI Official Synonym Full Names
T-box 1
NCBI Official Symbol
TBX1 [Similar Products]
NCBI Official Synonym Symbols
DGS; TGA; VCF; CAFS; CTHM; DGCR; DORV; VCFS; TBX1C; CATCH22
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NCBI Protein Information
T-box transcription factor TBX1
UniProt Protein Name
T-box transcription factor TBX1
UniProt Synonym Protein Names
Testis-specific T-box protein
Protein Family
T-box transcription factor
UniProt Gene Name
TBX1 [Similar Products]
UniProt Synonym Gene Names
T-box protein 1 [Similar Products]
NCBI Summary for TBX1
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TBX1
Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries ().
Research Articles on TBX1
1. Studied expression, function, and regulation of T-box transcription factor (TBX1), in human parathyroid ***** normal and tumor tissues.
Precautions
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Disclaimer
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