Full Product Name
CRKL Antibody, FITC conjugated
Product Synonym Names
Crk-like protein; CRKL
Product Gene Name
anti-CRKL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P46109
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Crk-like protein (98-303AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-31693 / sc-31694 / sc-319 / sc-9005
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CRKL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CRKL antibody
May mediate the transduction of intracellular signals.
Applications Tested/Suitable for anti-CRKL antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for CRKL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005198.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005207.3
[Other Products]
UniProt Primary Accession #
P46109
[Other Products]
UniProt Secondary Accession #
A8KA44; D3DX35[Other Products]
UniProt Related Accession #
P46109[Other Products]
Molecular Weight
33,777 Da
NCBI Official Full Name
crk-like protein
NCBI Official Synonym Full Names
CRK like proto-oncogene, adaptor protein
NCBI Official Symbol
CRKL [Similar Products]
NCBI Protein Information
crk-like protein
UniProt Protein Name
Crk-like protein
Protein Family
Crk-like protein
UniProt Gene Name
CRKL [Similar Products]
UniProt Entry Name
CRKL_HUMAN
NCBI Summary for CRKL
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
UniProt Comments for CRKL
CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cell-cell adherens junction; cytosol; endosome
Molecular Function: protein binding; SH3/SH2 adaptor activity; signal transducer activity
Biological Process: activation of MAPKK activity; JNK cascade; positive regulation of cell proliferation; Ras protein signal transduction
Research Articles on CRKL
1. CrkL mediates CCL20/CCR6-induced epithelial-to-mesenchymal transition via Akt pathway, instead of Erk1/2 pathway in development of gastric cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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