Product Name
thromboxane A2 receptor (TBXA2R), Polyclonal Antibody
Full Product Name
Goat Anti-thromboxane A2 receptor (isoform beta) Antibody
Product Synonym Names
TBXA2R antibody; thromboxane A2 receptor antibody; BDPLT13 antibody; TXA2-R antibody; prostanoid TP receptor antibody
Product Gene Name
anti-TBXA2R antibody
[Similar Products]
Antibody/Peptide Pairs
TBXA2R peptide (MBS428812) is used for blocking the activity of thromboxane A2 receptor antibody (MBS423666)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
PFEPPTGKAL SRKD
Species Reactivity
Human
Tested: Human
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Immunogen
Peptide with sequence C-PFEPPTGKALSRKD, from the C Terminus of the protein sequence according to NP_963998.2.
Note
This antibody is expected to recognize the reported isoform beta (NP_963998.2) only.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TBXA2R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TBXA2R antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-TBXA2R antibody
Western Blot: Approx 55kDa band observed in Human Lung and Placenta lysates (calculated MW of 44.2kDa according to NP_963998.2). The observed molecular weight corresponds to the glycosylated form. Recommended concentration: 0.03-0.1ug/ml.
Peptide ELISA: Antibody detection limit dilution 1:128000.
Western Blot (WB) of anti-TBXA2R antibody
(0.03ug/ml) staining of Human Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
NCBI/Uniprot data below describe general gene information for TBXA2R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_963998.2
[Other Products]
NCBI GenBank Nucleotide #
NM_201636.2
[Other Products]
UniProt Secondary Accession #
O75228; Q6DK52; Q9UCY1; Q9UCY2[Other Products]
UniProt Related Accession #
P21731[Other Products]
Molecular Weight
44,205 Da
NCBI Official Full Name
thromboxane A2 receptor isoform beta
NCBI Official Synonym Full Names
thromboxane A2 receptor
NCBI Official Symbol
TBXA2R [Similar Products]
NCBI Official Synonym Symbols
TXA2-R; BDPLT13
[Similar Products]
NCBI Protein Information
thromboxane A2 receptor
UniProt Protein Name
Thromboxane A2 receptor
UniProt Synonym Protein Names
Prostanoid TP receptor
Protein Family
Thromboxane A2 receptor
UniProt Gene Name
TBXA2R [Similar Products]
UniProt Synonym Gene Names
TXA2-R [Similar Products]
UniProt Entry Name
TA2R_HUMAN
NCBI Summary for TBXA2R
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for TBXA2R
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
Research Articles on TBXA2R
1. The results of this study show that TXA2R polymorphisms may affect platelet function and the risk of developing cerebral ischemia.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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