Full Product Name
CRMP2 Antibody FITC-Conjugated
Product Synonym Names
CRAM; DHPRP 2; Dihydropyrimidinase 2; DPYL 2; Musunc 33; N2A3; TOAD 64; ULIP 2 protein; Unc-33-like phosphoprotein 2 antibody
Product Gene Name
anti-CRMP2 antibody
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Matching Pairs
Antibody: CRMP2 (MBS541316)
Positive Control: CRMP2 (MBS542658)
Antibody/Peptide Pairs
CRMP2 peptide (MBS543205) is used for blocking the activity of CRMP2 antibody (MBS541316)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16555
Species Reactivity
Human, Mouse, Rat
Form/Format
FITC-Conjugated
Concentration
0.57 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken from within the region corresponding to AA 60-115 of the CRMP2 protein. The 26mer peptide was conserved in several other species. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero-bifunctional cross linker for immunogen preparation.
Molecular Function
Dihydropyrimidinase activity; developmental protein
Structure
Homotetramer and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Intteracts via its C-terminus with the C-terminus of CYF1P1/SRA1. Also interacts with HTR4, CLN6 and MICALL1.
Subcellular Location
Cytoplasm; Cytoskeleton; Membrane
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-CRMP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CRMP2 antibody
FITC-Conjugated Collapsin response mediated protein 2 Antibody
Involved in neuronal development and polarity, axon growth and guidance, neuronal growth cone collapse, and cell migration. Is needed for signalling by class 3 semaphorins and later remodeling of the cytoskeleton.
Applications Tested/Suitable for anti-CRMP2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CRMP2 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for CRMP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001184222.1
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NCBI GenBank Nucleotide #
NM_001197293.2
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UniProt Primary Accession #
Q16555
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UniProt Secondary Accession #
O00424; A8K5H2; B4DR31; D3DSS7[Other Products]
UniProt Related Accession #
Q16555[Other Products]
Molecular Weight
58,163 Da
NCBI Official Full Name
dihydropyrimidinase-related protein 2 isoform 1
NCBI Official Synonym Full Names
dihydropyrimidinase like 2
NCBI Official Symbol
DPYSL2 [Similar Products]
NCBI Official Synonym Symbols
DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2
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NCBI Protein Information
dihydropyrimidinase-related protein 2
UniProt Protein Name
Dihydropyrimidinase-related protein 2
UniProt Synonym Protein Names
Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2
UniProt Gene Name
DPYSL2 [Similar Products]
UniProt Synonym Gene Names
CRMP2; ULIP2; DRP-2; CRMP-2; ULIP-2 [Similar Products]
UniProt Entry Name
DPYL2_HUMAN
NCBI Summary for CRMP2
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for CRMP2
CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)).
Protein type: Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8p22-p21
Cellular Component: cell soma; cytosol; dendrite; growth cone; membrane; microtubule; mitochondrion; myelin sheath; protein complex; terminal button
Molecular Function: dihydropyrimidinase activity; microtubule binding; protein binding; protein kinase binding
Biological Process: axon guidance; cytoskeleton organization and biogenesis; endocytosis; nervous system development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; olfactory bulb development; positive regulation of glutamate secretion; regulation of axon extension; response to amphetamine; response to cocaine; response to drug; signal transduction; spinal cord development; synaptic vesicle transport
Research Articles on CRMP2
1. polymorphisms of the DPYSL2 gene in humans may be associated with the development of schizophrenia.
Precautions
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