Product Name
COL4A6, Polyclonal Antibody
Full Product Name
COL4A6 Polyclonal Antibody
Product Gene Name
anti-COL4A6 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14031
Other Notes
Small volumes of anti-COL4A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for COL4A6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001274689.1
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NCBI GenBank Nucleotide #
NM_001287760.1
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UniProt Primary Accession #
Q14031
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UniProt Secondary Accession #
Q12823; Q14053; Q5JYH6; Q5JYH8; Q9NQM5; Q9NTX3; Q9UJ76; Q9UMG6; Q9Y4L4[Other Products]
UniProt Related Accession #
Q14031[Other Products]
Molecular Weight
163,629 Da
NCBI Official Full Name
collagen alpha-6(IV) chain isoform 5
NCBI Official Synonym Full Names
collagen type IV alpha 6 chain
NCBI Official Symbol
COL4A6 [Similar Products]
NCBI Official Synonym Symbols
DFNX6; DELXq22.3; CXDELq22.3
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NCBI Protein Information
collagen alpha-6(IV) chain
UniProt Protein Name
Collagen alpha-6(IV) chain
UniProt Gene Name
COL4A6 [Similar Products]
NCBI Summary for COL4A6
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
UniProt Comments for COL4A6
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Research Articles on COL4A6
1. deletion breakpoints in five Alport syndrome-diffuse leiomyomatosis patients and show a contiguous COL4A6/COL4A5 deletion in each case, were characterized.
Precautions
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Disclaimer
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