GALNT3, cDNA Clone

For Research Use Only. Not for use in diagnostic procedures.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of GALNT3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

22,212 Da

polypeptide N-acetylgalactosaminyltransferase 3

polypeptide N-acetylgalactosaminyltransferase 3

Polypeptide N-acetylgalactosaminyltransferase 3

GalNAc-T3; pp-GaNTase 3  [Similar Products]

GALT3_HUMAN

This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008]

GALNT3: an enzyme that catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Plays a central role in phosphate homeostasis. Mutations cause cause familial tumoral calcinosis, a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Overexpressed in many differentiated carcinomas, suggesting that it may serve as a marker of tumor differentiation. Two alternatively spliced human isoforms have been described.

Protein type: Glycan Metabolism - O-glycan biosynthesis; EC 2.4.1.41; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 2q24-q31

Cellular Component: Golgi apparatus; Golgi membrane; membrane; perinuclear region of cytoplasm

Molecular Function: calcium ion binding; manganese ion binding; polypeptide N-acetylgalactosaminyltransferase activity

Biological Process: fibroblast growth factor receptor signaling pathway; O-glycan processing; protein amino acid O-linked glycosylation via serine; protein amino acid O-linked glycosylation via threonine

Disease: Tumoral Calcinosis, Hyperphosphatemic, Familial

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