Mannan-binding lectin serine protease 2 (Masp2), Recombinant Protein

Mannan-binding lectin serine protease 2; EC=3.4.21.104; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2Cleaved into the following 2 chains:; 1. Mannan-binding lectin serine protease 2 A chain; 2. Mannan-bindi

For Research Use Only. Not for use in diagnostic procedures.

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Masp2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase

Cardiovascular

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

20,974 Da

mannan-binding lectin serine peptidase 2

mannan-binding lectin serine protease 2; MBL-associated serine protease 2; mannose-binding protein-associated serine protease 2

Mannan-binding lectin serine protease 2

MASP-2  [Similar Products]

MASP2_MOUSE

MASP2: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Defects in MASP2 are the cause of MASP2 deficiency (MASPD). MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.104; Secreted; Secreted, signal peptide; Protease

Cellular Component: extracellular region

Molecular Function: peptidase activity; protein binding; hydrolase activity; serine-type peptidase activity; metal ion binding; serine-type endopeptidase activity; complement component C4b binding; calcium ion binding; calcium-dependent protein binding; catalytic activity

Biological Process: immune system process; innate immune response; proteolysis; complement activation, lectin pathway; complement activation, classical pathway; complement activation

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