Product Name
CA8, cDNA Clone
Full Product Name
CA8 cDNA Clone
Product Gene Name
CA8 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggacc tgagcttcat cgaagatacc gtcgccttcc ccgagaagga agaggatgag gaggaagaag aggagggtgt ggagtggggc tacgaggaag gtgttgagtg gggtctggtg tttcctgatg ctaatgggga ataccagtct cctattaacc taaactcaag agaggctagg tatgacccct cgctgttgga tgtccgcctc tccccaaatt atgtggtgtg ccgagactgt gaagtcacca atgatggaca taccattcag gttatcctga agtcaaaatc agttctttcg ggaggaccat tgcctcaagg gcatgagttt gaactgtacg aagtgagatt tcactgggga agagaaaacc agcgtggttc tgagcacacg gttaatttca aagcttttcc catggagctc catctgatcc actggaactc cactctgttt ggcagcattg atgaggctgt ggggaagccg cacggaatcg ccatcattgc tctgtttgtt cagataggaa aggaacatgt tggcttgaag gctgtgactg aaatcctcca agatattcag tataagggga agtccaaaac aataccttgc tttaatccta acactttatt accagaccct ctgctgcggg attactgggt gtatgaaggc tctctcacca tcccaccttg cagtgaaggt gtcacctgga tattattccg atacccttta actatatccc agctacagat agaagaattt cgaaggctga ggacacatgt taagggggca gaacttgtgg aaggctgtga tgggattttg ggagacaact ttcggcccac tcagcctctt agtgacagag tcattagagc tgcatttcag tag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CA8 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CA8. It may not necessarily be applicable to this product.
NCBI Accession #
BC069744
[Other Products]
UniProt Secondary Accession #
Q32MY2; A8K0A5; B3KQZ7[Other Products]
UniProt Related Accession #
P35219[Other Products]
Molecular Weight
32,973 Da
NCBI Official Full Name
Homo sapiens carbonic anhydrase VIII, mRNA
NCBI Official Synonym Full Names
carbonic anhydrase 8
NCBI Official Symbol
CA8 [Similar Products]
NCBI Official Synonym Symbols
CALS; CARP; CA-RP; CAMRQ3; CA-VIII
[Similar Products]
NCBI Protein Information
carbonic anhydrase-related protein
UniProt Protein Name
Carbonic anhydrase-related protein
UniProt Synonym Protein Names
Carbonic anhydrase VIII; CA-VIII
Protein Family
Carbonic anhydrase-related protein
UniProt Gene Name
CA8 [Similar Products]
UniProt Synonym Gene Names
CALS; CARP; CA-VIII [Similar Products]
UniProt Entry Name
CAH8_HUMAN
NCBI Summary for CA8
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Comments for CA8
CA8: Does not have a carbonic anhydrase catalytic activity. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3). CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation. Belongs to the alpha-carbonic anhydrase family.
Protein type: Energy Metabolism - nitrogen; Lyase
Chromosomal Location of Human Ortholog: 8q12.1
Molecular Function: protein binding
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 3
Research Articles on CA8
1. CA8 overexpression desensitizes neuronal cells to STS induced apoptotic stress and increases cell migration and invasion ability in neuronal cells.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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