Product Name
CRMP-2, Polyclonal Antibody
Full Product Name
CRMP-2 (phospho Ser522) Polyclonal Antibody
Product Gene Name
anti-CRMP-2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16555
Other Notes
Small volumes of anti-CRMP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CRMP-2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001184222.1
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NCBI GenBank Nucleotide #
NM_001197293.2
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UniProt Primary Accession #
Q16555
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UniProt Secondary Accession #
O00424; A8K5H2; B4DR31; D3DSS7[Other Products]
UniProt Related Accession #
Q16555[Other Products]
Molecular Weight
58,163 Da
NCBI Official Full Name
dihydropyrimidinase-related protein 2 isoform 1
NCBI Official Synonym Full Names
dihydropyrimidinase like 2
NCBI Official Symbol
DPYSL2 [Similar Products]
NCBI Official Synonym Symbols
DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2
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NCBI Protein Information
dihydropyrimidinase-related protein 2
UniProt Protein Name
Dihydropyrimidinase-related protein 2
UniProt Synonym Protein Names
Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2
UniProt Gene Name
DPYSL2 [Similar Products]
UniProt Synonym Gene Names
CRMP2; ULIP2; DRP-2; CRMP-2; ULIP-2 [Similar Products]
NCBI Summary for CRMP-2
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for CRMP-2
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Research Articles on CRMP-2
1. cross-talk between distinct CRMP2 posttranslational modifications is a key factor in determining NaV1.7 trafficking and localization
Precautions
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Disclaimer
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