ZEB2/SIP-1, Polyclonal Antibody

Rabbit Polyclonal (IgG) to Human ZEB2/SIP-1; ZEB2; KIAA0569; SIP1; SMADIP1; ZFX1B; SIP-1; SMAD interacting protein 1; Smad-interacting protein 1; ZFHX1B; Zinc finger homeobox 1b; HSPC082

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

ZEB2 antibody detects endogenous levels of ZEB2.

Immunoaffinity Purified

PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol.

Store at -20 degree C.

Small volumes of anti-ZEB2/SIP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ZEB2 is a member of the Zfh1 family of 2-handed zinc finger/homeodomainproteins. It is located in the nucleus and functions as a DNA-bindingtranscriptional repressor that interacts with activated SMADs. Mutationsin this gene are associated with Hirschsprung disease/Mowat-Wilsonsyndrome. Alternatively spliced transcript variants have been found forthis gene.

ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

ELISA: 1:10000
IHC-P: 1:50
WB: 1:500-1:1000

Human Fetal Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Western blot analysis of the lysates from HepG2 cells using ZEB2 antibody.

133,806 Da

zinc finger E-box binding homeobox 2

zinc finger E-box-binding homeobox 2

Zinc finger E-box-binding homeobox 2

KIAA0569; SIP1; ZFHX1B; ZFX1B; SMADIP1  [Similar Products]

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]

Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.

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