Product Name
Plakophilin 1 (PKP1), Polyclonal Antibody
Full Product Name
Plakophilin 1 antibody
Product Synonym Names
Polyclonal Plakophilin 1; Anti Plakophilin 1; Plakophilin 1; Plakophilin -1
Product Gene Name
anti-PKP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13835
Species Reactivity
Bovine, Mouse, Frog
Specificity
Human Plakophilin 1
Form/Format
Supplied in liquid form. Contains 0.09% sodium azide
Biological Significance
Plakophilin-1 is a protein that in humans is encoded by the PKP1 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome.
Immunogen
Plakophilin 1 antibody was raised in Guinea Pig using human recombinant plakophilin 1 as the immunogen.
Preparation and Storage
Store at 2-8 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-PKP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PKP1 antibody
Guinea Pig polyclonal Plakophilin 1 antibody
Product Categories/Family for anti-PKP1 antibody
Cell Biology
Applications Tested/Suitable for anti-PKP1 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-PKP1 antibody
IHC: 1:100
WB: 1:1000
NCBI/Uniprot data below describe general gene information for PKP1. It may not necessarily be applicable to this product.
NCBI Accession #
CAA98022.1
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UniProt Primary Accession #
Q13835
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UniProt Secondary Accession #
O00645; Q14CA0; Q15152[Other Products]
UniProt Related Accession #
Q13835[Other Products]
Molecular Weight
80,497 Da[Similar Products]
NCBI Official Full Name
plakophilin 1
NCBI Official Synonym Full Names
plakophilin 1
NCBI Official Symbol
PKP1 [Similar Products]
NCBI Official Synonym Symbols
B6P
[Similar Products]
NCBI Protein Information
plakophilin-1
UniProt Protein Name
Plakophilin-1
UniProt Synonym Protein Names
Band 6 protein; B6P
Protein Family
Plakophilin
UniProt Gene Name
PKP1 [Similar Products]
UniProt Synonym Gene Names
B6P [Similar Products]
UniProt Entry Name
PKP1_HUMAN
NCBI Summary for PKP1
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Comments for PKP1
plakophilin 1: Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis. Defects in PKP1 are the cause of ectodermal dysplasia- skin fragility syndrome (EDSFS); also known as McGrath syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSFS is characterized by features of both cutaneous fragility and congenital ectodermal dysplasia affecting abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: nucleoplasm; desmosome; intracellular membrane-bound organelle; plasma membrane; intermediate filament; nucleus
Molecular Function: signal transducer activity; protein binding; intermediate filament binding; structural constituent of epidermis; lamin binding
Biological Process: cell-cell adhesion; apoptosis; multicellular organismal development; intermediate filament bundle assembly; signal transduction; cell adhesion; cell structure disassembly during apoptosis
Disease: Ectodermal Dysplasia/skin Fragility Syndrome
Research Articles on PKP1
1. cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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