Product Name
Interferon lambda-3 (IFNL3), Polyclonal Antibody
Full Product Name
Anti-Interferon lambda-3 Antibody
Product Synonym Names
IL28B; IL28C; ZCYTO22; Interferon lambda-3; IFN-lambda-3; Cytokine Zcyto22; Interleukin-28B; IL-28B; Interleukin-28C; IL-28C
Product Gene Name
anti-IFNL3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8IZI9
Specificity
Recognizes endogenous levels of Interferon lambda-3 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human Interferon lambda-3
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-IFNL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IFNL3 antibody
Rabbit polyclonal antibody to Interferon lambda-3
Applications Tested/Suitable for anti-IFNL3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-IFNL3 antibody
WB: 1/500 - 1/2000; IHC: 1/50 - 1/200
Western Blot (WB) of anti-IFNL3 antibody
Western blot analysis of Interferon lambda-3 expression in HEK293T (A) whole cell lysates.
Immunohistochemistry (IHC) of anti-IFNL3 antibody
Immunohistochemical analysis of Interferon lambda-3 staining in rat brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
NCBI/Uniprot data below describe general gene information for IFNL3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_742151.2
[Other Products]
NCBI GenBank Nucleotide #
NM_172139.2
[Other Products]
UniProt Primary Accession #
Q8IZI9
[Other Products]
UniProt Secondary Accession #
Q6VN56; Q7Z4J3; Q8IWL6; A2BDE1[Other Products]
UniProt Related Accession #
Q8IZI9[Other Products]
Molecular Weight
21,706 Da
NCBI Official Full Name
interferon lambda-3
NCBI Official Synonym Full Names
interferon, lambda 3
NCBI Official Symbol
IFNL3 [Similar Products]
NCBI Official Synonym Symbols
IL28B; IL28C; IL-28B
[Similar Products]
NCBI Protein Information
interferon lambda-3
UniProt Protein Name
Interferon lambda-3
UniProt Synonym Protein Names
Cytokine Zcyto22; Interleukin-28B; IL-28B; Interleukin-28C; IL-28C
Protein Family
Interferon
UniProt Gene Name
IFNL3 [Similar Products]
UniProt Synonym Gene Names
IL28B; IL28C; ZCYTO22; IFN-lambda-3; IL-28B; IL-28C [Similar Products]
UniProt Entry Name
IFNL3_HUMAN
NCBI Summary for IFNL3
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
UniProt Comments for IFNL3
IL-28B: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: extracellular region; extracellular space; intracellular
Molecular Function: cytokine activity; receptor binding
Biological Process: defense response to virus; innate immune response; JAK-STAT cascade; negative regulation of viral genome replication; positive regulation of immune response; regulation of T cell activation
Disease: Hepatitis C Virus, Susceptibility To
Research Articles on IFNL3
1. The association of IL-28B and CTLA-4 polymorphisms and HCV F protein in the risk and chronicity of HCV infection in Chinese Han population in Southeast China.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
