Full Product Name
Anti-EPB41 Antibody
Product Gene Name
anti-EPB41 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Specificity
Western blot analysis of extracts of various cell lines, using EPB41 antibody. Immunofluorescence analysis of U2OS cell using EPB41 antibody. Blue: DAPI for nuclear staining.
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human EPB41
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-EPB41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EPB41 antibody
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Applications Tested/Suitable for anti-EPB41 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-EPB41 antibody
WB: 1:500 - 1:2000
IHC: 1:50- 1:200
IF: 1:50- 1:200
Western Blot (WB) of anti-EPB41 antibody
Immunofluorescence (IF) of anti-EPB41 antibody
NCBI/Uniprot data below describe general gene information for EPB41. It may not necessarily be applicable to this product.
NCBI Accession #
AAH96105.2
[Other Products]
UniProt Secondary Accession #
P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579; B1ALH8; B1ALH9; D3DPM9; D3DPN0[Other Products]
UniProt Related Accession #
P11171[Other Products]
Molecular Weight
81,235 Da
NCBI Official Full Name
EPB41 protein
NCBI Official Synonym Full Names
erythrocyte membrane protein band 4.1
NCBI Official Symbol
EPB41 [Similar Products]
NCBI Official Synonym Symbols
HE; EL1; 4.1R
[Similar Products]
NCBI Protein Information
protein 4.1
UniProt Protein Name
Protein 4.1
UniProt Synonym Protein Names
4.1R; Band 4.1; EPB4.1
Protein Family
Erythroid protein
UniProt Gene Name
EPB41 [Similar Products]
UniProt Synonym Gene Names
E41P; P4.1 [Similar Products]
NCBI Summary for EPB41
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for EPB41
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
Research Articles on EPB41
1. The 4.1R, 4.1N and 4.1B are all expressed at the lateral membrane as well as cytoplasm of epithelial cells, suggesting a potentially redundant role of these proteins.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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