Full Product Name
EPB41 Antibody
Product Synonym Names
4.1R; 41; band 4.1; E41P; EPB4.1; erythrocyte membrane protein band 4.1; P4.1; protein 4.1
Product Gene Name
anti-EPB41 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11171
Species Reactivity
Human, Mouse
Specificity
EPB41 Antibody detects endogenous levels of total EPB41 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human EPB41.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-EPB41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-EPB41 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-EPB41 antibody
WB: 1:500~1:1000
ELISA: 1:5000
Western Blot (WB) of anti-EPB41 antibody
Western blot analysis of lysates from HepG2 cells treated with PMA 125ng/ml 30', using EPB41 Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for EPB41. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001159477.1
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NCBI GenBank Nucleotide #
NM_001166005.1
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UniProt Primary Accession #
P11171
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UniProt Secondary Accession #
P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579; B1ALH8; B1ALH9; D3DPM9; D3DPN0[Other Products]
UniProt Related Accession #
P11171[Other Products]
NCBI Official Full Name
protein 4.1 isoform 1
NCBI Official Synonym Full Names
erythrocyte membrane protein band 4.1
NCBI Official Symbol
EPB41 [Similar Products]
NCBI Official Synonym Symbols
HE; EL1; 4.1R
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NCBI Protein Information
protein 4.1
UniProt Protein Name
Protein 4.1
UniProt Synonym Protein Names
4.1R; Band 4.1; EPB4.1
Protein Family
Erythroid protein
UniProt Gene Name
EPB41 [Similar Products]
UniProt Synonym Gene Names
E41P; P4.1 [Similar Products]
NCBI Summary for EPB41
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for EPB41
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).
Research Articles on EPB41
1. Using Next-Generation sequencing, we identified the causative genetic mutations in fifteen patients with clinically suspected hereditary elliptocytosis and hereditary pyropoikilocytosis and correlated the identified mutations with the clinical phenotype and ektacytometry profile.
Precautions
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Disclaimer
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