Product Name
GAS41, Blocking Peptide
Full Product Name
GAS41 (YEATS4/NuBI-1) Antibody (N-term A31) Blocking Peptide
Product Synonym Names
YEATS domain-containing protein 4; Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1; NuBI-1; NuBI1; YEATS4; GAS41
Product Gene Name
GAS41 blocking peptide
[Similar Products]
Product Synonym Gene Name
YEATS4[Similar Products]
Antibody/Peptide Pairs
GAS41 peptide (MBS9231418) is used for blocking the activity of GAS41 (YEATS4/NuBI-1) antibody (MBS9213770)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95619
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human NuBI-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Lyophilized with 100% acetonitrile and is supplied as a powder.
Reconstitution
Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of GAS41 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GAS41 blocking peptide
NuBI-1 is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. The gene for this protein has been shown to be amplified in tumors.
NCBI/Uniprot data below describe general gene information for GAS41. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006521.1
[Other Products]
NCBI GenBank Nucleotide #
NM_006530.4
[Other Products]
UniProt Primary Accession #
O95619
[Other Products]
UniProt Secondary Accession #
Q9CR11[Other Products]
UniProt Related Accession #
O95619[Other Products]
NCBI Official Full Name
YEATS domain-containing protein 4 isoform 1
NCBI Official Synonym Full Names
YEATS domain containing 4
NCBI Official Symbol
YEATS4 [Similar Products]
NCBI Official Synonym Symbols
YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
[Similar Products]
NCBI Protein Information
YEATS domain-containing protein 4
UniProt Protein Name
YEATS domain-containing protein 4
UniProt Synonym Protein Names
Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1
UniProt Gene Name
YEATS4 [Similar Products]
UniProt Synonym Gene Names
GAS41; Gas41; NuBI-1; NuBI1 [Similar Products]
UniProt Entry Name
YETS4_HUMAN
NCBI Summary for GAS41
The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
UniProt Comments for GAS41
YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 12q13-q15
Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; cytoplasm; nucleolus
Molecular Function: protein C-terminus binding; protein binding; DNA binding; structural constituent of cytoskeleton; transcription factor activity
Biological Process: mitosis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of growth; positive regulation of transcription, DNA-dependent
Research Articles on GAS41
1. Cellular and structural studies revealed that GAS41 is a histone lysine succinylation reader owing to a protonated histidine residue located inside the pocket.
Precautions
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Disclaimer
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