YEATS Domain Containing 4, Monoclonal Antibody

Anti -YEATS Domain Containing 4 (YEATS4, 4930573H17Rik, B230215M10Rik, YAF9)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 12; NC_000012.11 (69753532..69784576). Location: 12q13-q15

Monoclonal

IgG1

8C360

Mouse

Recognizes human YEATS Domain Containing 4.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-YEATS4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription.

Antibodies; Abs to Transcription Factors

Western Blot (WB)

Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000-1:2000

26,499 Da[Similar Products]

YEATS domain containing 4

YEATS domain-containing protein 4; nuBI1; NuMA binding protein 1; nuMA-binding protein 1; glioma-amplified sequence 41; glioma-amplified sequence-41

YEATS domain-containing protein 4

GAS41  [Similar Products]

YETS4_HUMAN

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. [provided by RefSeq]

YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 12q13-q15

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; cytoplasm; nucleolus

Molecular Function: protein C-terminus binding; protein binding; DNA binding; structural constituent of cytoskeleton; transcription factor activity

Biological Process: mitosis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of growth

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