Full Product Name
C1QA Polyclonal Antibody
Product Synonym Names
Complement C1q subcomponent subunit A; C1QA
Product Gene Name
anti-C1QA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02745
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-C1QA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-C1QA antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-C1QA antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for C1QA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001334394.1
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NCBI GenBank Nucleotide #
NM_001347465.1
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UniProt Primary Accession #
P02745
[Other Products]
UniProt Secondary Accession #
Q5T963; B2R4X2[Other Products]
UniProt Related Accession #
P02745[Other Products]
NCBI Official Full Name
complement C1q subcomponent subunit A
NCBI Official Synonym Full Names
complement C1q A chain
NCBI Official Symbol
C1QA [Similar Products]
NCBI Protein Information
complement C1q subcomponent subunit A
UniProt Protein Name
Complement C1q subcomponent subunit A
Protein Family
Complement C1q subcomponent
UniProt Gene Name
C1QA [Similar Products]
NCBI Summary for C1QA
This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
UniProt Comments for C1QA
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Research Articles on C1QA
1. this study shows that regulatory dendritic cells can mediate a potent direct anti-inflammatory activity via the expression and/or secretion of molecules such as C1q, independently of their capacity to expand the pool of regulatory T cells
Precautions
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Disclaimer
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