YEATS4, Polyclonal Antibody

YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purification

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-YEATS4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms.

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:2000, IHC: 1:50-1:200

Western blot analysis of extracts of various cell lines, using YEATS4 antibody.

Calculated MW: 26kDa

YEATS domain containing 4

YEATS domain-containing protein 4

YEATS domain-containing protein 4

GAS41; Gas41; NuBI-1; NuBI1  [Similar Products]

YETS4_HUMAN

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 12q13-q15

Cellular Component: NuA4 histone acetyltransferase complex; nuclear matrix; nucleoplasm

Molecular Function: DNA binding; protein binding; protein C-terminus binding; structural constituent of cytoskeleton; transcription factor activity

Biological Process: establishment and/or maintenance of chromatin architecture; mitosis; positive regulation of transcription, DNA-dependent; regulation of growth; transcription, DNA-dependent

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