Product Name
Kv7.3/KCNQ3, Polyclonal Antibody
Full Product Name
Kv7.3/KCNQ3 Antibody
Product Gene Name
anti-Kv7.3/KCNQ3 antibody
[Similar Products]
Product Synonym Gene Name
KCNQ2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43525
Species Reactivity
Human, Mouse, Rat
Specificity
Kv7.3/KCNQ3 Antibody detects endogenous levels of total Kv7.3/KCNQ3 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-Kv7.3/KCNQ3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-Kv7.3/KCNQ3 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-Kv7.3/KCNQ3 antibody
IHC: 1:50~1:100
ELISA: 1:1000
Immunohistochemistry (IHC) of anti-Kv7.3/KCNQ3 antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv7.3/KCNQ3 Antibody. The picture on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for Kv7.3/KCNQ3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001191753.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001204824.1
[Other Products]
UniProt Primary Accession #
O43525
[Other Products]
UniProt Secondary Accession #
A2VCT8; B4DJY4; E7EQ89[Other Products]
UniProt Related Accession #
O43525[Other Products]
NCBI Official Full Name
potassium voltage-gated channel subfamily KQT member 3 isoform 2
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily Q member 3
NCBI Official Symbol
KCNQ3 [Similar Products]
NCBI Official Synonym Symbols
EBN2; BFNC2; KV7.3
[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 3
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 3
UniProt Synonym Protein Names
KQT-like 3; Potassium channel subunit alpha KvLQT3; Voltage-gated potassium channel subunit Kv7.3
UniProt Gene Name
KCNQ3 [Similar Products]
NCBI Summary for Kv7.3/KCNQ3
This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for Kv7.3/KCNQ3
Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.
Research Articles on Kv7.3/KCNQ3
1. In the present work, a pharmacophore-based 3D-QSAR model was generated for a series of N-pyridyl and pyrimidine benzamides possessing KCNQ2/Q3 opening activity. The pharmacophore model generated contains one hydrogen bond donor (D), one hydrophobic (H), and two aromatic rings (R). They are the crucial molecular write-up detailing predicted binding efficacy of high affinity and low affinity ligands for KCNQ2/Q3 opening a
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