Product Name
Glycine Receptor Subunit alpha 2 (GLRA2), Cell Line
Full Product Name
Glycine Receptor Subunit alpha 2 (GLRA2) Stable Cell Line, CHO
Product Gene Name
GLRA2 cell line
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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3D Structure
ModBase 3D Structure for P23416
Shipping Conditions
Shipped on dry ice. Please ensure dry ice is still present in the package upon receipt.
Other Notes
Small volumes of GLRA2 cell line vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for GLRA2 cell line
Cell Lines For Membrane Receptor Research; Ion Channel Stable Cell Lines
NCBI/Uniprot data below describe general gene information for GLRA2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002054.1
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NCBI GenBank Nucleotide #
NM_002063.4
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UniProt Primary Accession #
P23416
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UniProt Secondary Accession #
Q53YX7; Q6ICQ0; Q99862; A8K0J6; B2R6I8; B7Z4F5; J3KQ59[Other Products]
UniProt Related Accession #
P23416[Other Products]
Molecular Weight
51,986 Da
NCBI Official Full Name
glycine receptor subunit alpha-2 isoform A
NCBI Official Synonym Full Names
glycine receptor alpha 2
NCBI Official Symbol
GLRA2 [Similar Products]
NCBI Official Synonym Symbols
GLR
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NCBI Protein Information
glycine receptor subunit alpha-2
UniProt Protein Name
Glycine receptor subunit alpha-2
Protein Family
Glycine receptor
UniProt Gene Name
GLRA2 [Similar Products]
NCBI Summary for GLRA2
The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
UniProt Comments for GLRA2
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).
Research Articles on GLRA2
1. data show that the current-voltage relationships of homomeric channels formed by the alpha2 or alpha3 subunits change upon receptor desensitization from a linear to an inwardly rectifying shape, in contrast to their heteromeric counterparts.
Precautions
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