Serotonin Receptor 1A, Monoclonal Antibody

Anti -Serotonin Receptor 1A

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_006584.2 (52876052..52877323, complement)

Monoclonal

IgM,k

11C254

Mouse

Recognizes rat Seratonin receptor 1A. Species Crossreactivity: human.

Highly Purified
Purified by ion exchange chromatography.

Supplied as a liquid in PBS, 0.05% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-HTR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Serotonin Receptor 1A, also known as 5-hydroxytryptamine receptor 1A, is a member of the G protein-coupled receptor family. Serotonin Receptor 1A has been found to be expressed highly in the septum and hippocampus. Serotonin Receptor 1A seems to have an inhibitory effect on Ca2+ channels, via N-channels and L-channels. The receptor actuates voltage-sensitive slowing using the N-channels and actuates steady state inhibition using the L-channels.

Antibodies; Abs to Serotonin Receptors

Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 0.5ug/ml detects Serotonin Receptor 1A on 10ug of rat brain tissue lysate. Band is observed at ~40kD. Calculated MW is 46kD.
Immunohistochemistry: 1:400 detects Serotonin Receptor 1A in normal human brain tissue.

46,356 Da[Similar Products]

5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A receptor; serotonin receptor 1A

5-hydroxytryptamine receptor 1A

5HT1A_CANFA

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

Subcellular location: Cell membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

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