Product Name
BMP-6, Recombinant Protein
Popular Item
Full Product Name
Recombinant Human BMP-6
Product Synonym Names
Recombinant Human BMP-6
Product Gene Name
BMP-6 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
VSSASDYNS SELKTACRK HELYVSFQD LGWQDWIIA PKGYAANYC DGECSFPLN AHMNATNHA IVQTLVHLM NPEYVPKPC CAPTKLNAI SVLYFDDNS NVILKKYRN MVVRACGCH
3D Structure
ModBase 3D Structure for P22004
Species Reactivity
Species Reactivity: Human
Cross Reactivity: Mouse
Purity/Purification
> = 95% as determined by SDS-PAGE Analysis.
Form/Format
Sterile filtered through a 0.2 micron filter. Lyophilized from 10mM Tris, pH 9.0.
Biological Activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 ug/ml.
Protein Content
Verified by UV Spectroscopy and/or SDS-PAGE gel.
Endotoxin
Endotoxin level is < 0.1 ng/ug of protein <1 EU/ug).
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1 % BSA) and store in working aliquots at -20 degree C to -80 degree C.
Preparation and Storage
At -20 degree C
Other Notes
Small volumes of BMP-6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BMP-6 recombinant protein
TGF-beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Product Categories/Family for BMP-6 recombinant protein
Stem Cell Research; Apoptosis; Angiogenesis; Bone Biology; Proliferation and Cell Cycle
NCBI/Uniprot data below describe general gene information for BMP-6. It may not necessarily be applicable to this product.
NCBI Accession #
P22004.1
[Other Products]
UniProt Primary Accession #
P22004
[Other Products]
UniProt Secondary Accession #
Q5TCP3[Other Products]
UniProt Related Accession #
P22004[Other Products]
Molecular Weight
57,226 Da
NCBI Official Full Name
Bone morphogenetic protein 6
NCBI Official Synonym Full Names
bone morphogenetic protein 6
NCBI Official Symbol
BMP6 [Similar Products]
NCBI Official Synonym Symbols
VGR; VGR1
[Similar Products]
NCBI Protein Information
bone morphogenetic protein 6; BMP-6; VGR-1; VG-1-R; VG-1-related protein; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related)
UniProt Protein Name
Bone morphogenetic protein 6
UniProt Synonym Protein Names
VG-1-related protein; VG-1-R; VGR-1
UniProt Gene Name
BMP6 [Similar Products]
UniProt Synonym Gene Names
VGR; BMP-6; VG-1-R; VGR-1 [Similar Products]
UniProt Entry Name
BMP6_HUMAN
NCBI Summary for BMP-6
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]
UniProt Comments for BMP-6
BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 6p24-p23
Cellular Component: extracellular space; cytoplasm
Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding
Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; regulation of apoptosis; BMP signaling pathway; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; kidney development; inflammatory response; response to iron ion; skeletal development; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; positive regulation of protein secretion; eye development; regulation of MAPKKK cascade; cartilage development; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth
Research Articles on BMP-6
1. these data highlight a therapeutically innovative role for BMP6 by providing a means to enhance the amount of myogenic lineage derived brown fat.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
