TMPRSS3, Polyclonal Antibody

Anti -TMPRSS3, ID (Transmembrane Protease, Serine 3, Tumor-associated Differentially-expressed Gene 12 Protein, Serine Protease TADG-12, UNQ323/PRO382, TADG12, ECHOS1)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 21; NC_000021.8 (43791996..43816200, complement). Location: 21q22.3

Polyclonal

IgG

Rabbit

Recognizes human TMPRSS3.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-TMPRSS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

TMPRSS3 belongs to the serine protease family. This protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders.

Antibodies; Abs to Enzymes, Protease (Proteinase, Peptidase)

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

37,447 Da[Similar Products]

transmembrane protease, serine 3

transmembrane protease serine 3; OTTHUMP00000109343; OTTHUMP00000109344; OTTHUMP00000109345; OTTHUMP00000109346; serine protease TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 protein

Potential serine protease TMPRSS3

Q8WY52_HUMAN

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq]

TMPRSS3: Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8). DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10). Belongs to the peptidase S1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.4.21.-; Protease; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: endoplasmic reticulum membrane; cell soma; endoplasmic reticulum; integral to membrane

Molecular Function: sodium channel regulator activity; serine-type endopeptidase activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; cellular sodium ion homeostasis; sensory perception of sound; proteolysis

Disease: Deafness, Autosomal Recessive 8

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